The Genetic Basis of Muscle Strength
A study conducted at the University of Jyväskylä in Finland has shown that a genetic predisposition for higher muscle strength predicts a longer lifespan and a lower risk for developing common diseases. The study, which used the internationally unique FinnGen dataset, found that a genome-wide polygenic score for muscle strength was associated with a lower risk of mortality and common diseases, including cardiometabolic and pulmonary diseases, musculoskeletal and connective tissue diseases, falls and fractures, mental health and cognitive disorders, cancers, and overall mortality.
Genetics and Muscle Strength
The study also found that the genetic predisposition for higher muscle strength was associated with a lower risk of frailty, a condition characterized by weakness, fatigue, and reduced physical function. The findings suggest that genetics play a significant role in muscle strength and health outcomes in older adults.