Investigators discovered that obesity causes permanent changes in the striatum, a region associated with food acquisition, which continues to seek food even after consumption of lipids or fats. These alterations are accompanied by reduced dopamine release, impairing the brain’s ability to promote satisfaction following meals. Moreover, these modifications persisted despite participants losing 10% of their body weight over three months, suggesting that the effects of obesity on the brain might be irreversible.
Uncovering the Long-Term Effects of Obesity on the Brain’s Appetite Center
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