The study has shown that MAGEA expression is significantly higher in advanced stages of bladder cancer, indicating its potential role in tumor progression. Furthermore, the researchers have identified genomic alterations in MAGEA family members, which could contribute to cancer development and progression.
The study has also demonstrated that MAGE-A10 protein expression is associated with advanced high-grade serous ovarian cancer, suggesting its potential as a biomarker for this type of cancer. Moreover, the MAGE protein family has been shown to play emerging roles in stress response pathways, highlighting their potential as therapeutic targets.
The research on MAGE proteins is particularly significant in the context of cancer drug resistance. MAGE proteins have been shown to play a role in cancer drug resistance, and the identification of small molecules that inhibit their interactions with other proteins could lead to the development of new drugs that can overcome this resistance.