In a groundbreaking study, researchers have identified 95 regions of the genome linked to the risk of developing post-traumatic stress disorder (PTSD). This discovery, made by analyzing the genetic data of over 1.2 million individuals, marks a significant step forward in understanding the complex interplay between genetics and PTSD.
Significant Findings
The study identified 95 genome-wide significant loci associated with PTSD risk, with 80 of them being new. These loci are linked to various neurobiological systems relevant to PTSD pathophysiology, including neurotransmitter and ion channel synaptic modulators, developmental and axon guidance factors, synaptic structure and function genes, and endocrine or immune regulators.