Alzheimer’s disease is a major global medical, social, and economic burden, with more than 55 million people affected worldwide. The disease typically manifests as progressive memory decline accompanied by other cognitive dysfunctions, such as visuospatial abnormalities, navigation difficulties, executive problems, and language disturbances.
The pathogenesis of Alzheimer’s disease involves various pathophysiological events, including the accumulation of amyloid and tau, neuro-inflammation, and neuronal injury. The key event in Alzheimer’s disease pathogenesis is believed to be Aβ accumulation, which leads to the formation of plaques and neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau.
Potential Neuroprotective Effects of HIV Drugs
The recent study suggests that common HIV drugs, specifically non-nucleoside reverse transcriptase inhibitors (NNRTIs), may have neuroprotective effects, potentially reducing the risk of Alzheimer’s disease. The study found that NNRTIs, such as efavirenz, nevirapine, and rilpivirine, may be able to reduce the risk of Alzheimer’s disease.