Hundreds of RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma.
RNA Modifications and Brain Functions
RNA modifications play a crucial role in numerous brain functions, such as neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, and neurodegeneration. These modifications can impact gene expression, mRNA stability, and protein translation, ultimately influencing various aspects of brain health and disease.
Implications in Brain Disorders
Deficiencies in the machineries that modulate RNA modifications have been linked to a wide range of brain disorders, including microcephaly, intellectual disability, seizures, psychiatric disorders, and brain cancers like glioblastoma. Understanding the complex interplay between RNA modifications and brain function is crucial for developing targeted therapies and improving patient outcomes.