Researchers from Boston University School of Public Health (BUSPH) and UTHealth Houston School of Public Health led the study, published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. By employing whole genome sequencing, they identified 17 significant variants associated with Alzheimer’s disease in five distinct genomic regions.
Among the discovered variants, the KAT8 variant stood out as particularly notable. Associated with Alzheimer’s disease in both single and rare variant analyses, it holds promise as a potential target for future research efforts. Additionally, several rare TREM2 variants were found to be associated with the condition, further emphasizing the importance of whole genome sequencing data in advancing our understanding of Alzheimer’s disease.